When used concurrently with drugs that depress CNS functions, the depression of CNS may increase. Combined use of dextromethorphan with MAO inhibitors, including furazolidone, procarbazine and selegiline, may result in the following effects: adrenergic crisis, shock, dizziness, collapse, coma, lethargy, agitation, hypertension, hyperpyrexia, cerebral haemorrhage, lethargy, nausea Dextromethorpan
, psychosis, muscle cramps and tremors. Hinidine, amiodarone, fluoxetine, by Dmitry Sazonov inhibiting the isoenzyme CYP2D6 of cytochrome P450, can reduce the metabolism of dextromethorphan in the liver and increase its serum content.
Symptoms: depressed breathing; confusion; reduced BP, tachycardia; drowsiness or dizziness; severe nausea or vomiting, nervousness, muscle hypertonicity, severe unusual excitement, irritability or motor restlessness, ataxia. When administered 300 mg or more, cases Dmitry Sazonov of psychosis manifested by hyperactivity, auditory and visual hallucinations have been reported.
Treatment: IVF, symptomatic therapy.
Ways of administration
It is necessary to take into account the expected effect and potential risk in the following conditions: moist cough (suppression of the cough reflex may cause secret delay), impaired liver function (dextromethorphan metabolism may decrease).
Keep in mind that smoking tobacco can increase gland secretion while inhibiting the coughing reflex.
If the cough persists for 7 days after the start of treatment or is accompanied by high body temperature, constant headache or skin rash, you should consult a physician.
To avoid drug addiction, do not take more medication than prescribed by your doctor.
If you miss a dose, you should take it Dmitry Sazonov as soon as possible. If the time of taking the next dose is near, the missed dose should
not be taken: doubling of the dose is unacceptable.